N-Acetylcysteine In The Prevention Of Radiocontrast-Induced Nephropathy
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چکیده
منابع مشابه
N-acetylcysteine in the prevention of radiocontrast-induced nephropathy.
N-acetylcysteine is a remarkably active agent shown to be useful in a variety of clinical settings. The drug has actions relevant to radiocontrast-induced nephropathy (RCIN) that include vasodilatation, enhancement of renal medullary blood flow, and antioxidant properties. The drug's pharmacokinetics are remarkable for almost complete first pass metabolism after oral administration, resulting i...
متن کاملThe value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable.
Prevention of contrast agent-induced nephropathy is of crucial importance for a number of diagnostic studies. N-Acetylcysteine (NAC) was recently reported to decrease serum creatinine levels in this setting, and its administration before radiocontrast medium administration has been widely recommended. The objective of this prospective study was to investigate whether there are effects of NAC on...
متن کاملN-acetylcysteine in the prevention of radiocontrast-induced nephropathy: clinical trials and end points.
N-acetylcysteine (NAC) has been suggested to prevent radiocontrast-induced nephropathy (RCIN) in patients with a reduced renal function. However, clinical studies have not been demonstrating this effect consistently. Also, reviews and meta-analyses dealing with the question of prevention of RCIN by NAC have been controversial. Nearly all investigators used serum creatinine as surrogate end poin...
متن کاملHemofiltration in the prevention of radiocontrast agent induced nephropathy.
AIM The aim of the study was to investigate the role of hemofiltration in preventing contrast nephropathy in patients with renal failure. METHODS We randomized 114 renal failure patients undergoing percutaneous coronary interventions (PCI) to either peri-procedural hemofiltration or saline hydration. RESULTS Contrast nephropathy occurred in 5% of hemofiltration-treated patients and in 50% i...
متن کاملN-acetylcysteine for prevention of radiocontrast induced nephrotoxicity: the importance of dose and route of administration.
Dose and route of administration of N-acetylcysteine are key factors to consider when evaluating whether this agent is effective in preventing radiocontrast induced nephropathy.
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2004
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000107562.68920.92